<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd">
<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<title>SEC FORM 
            4</title>
<style type="text/css">
              .FormData {color: blue; background-color: white; font-size: small; font-family: Times, serif;}
              .FormDataC {color: blue; background-color: white; font-size: small; font-family: Times, serif; text-align: center;}
              .FormDataR {color: blue; background-color: white; font-size: small; font-family: Times, serif; text-align: right;}
              .SmallFormData {color: blue; background-color: white; font-size: x-small; font-family: Times, serif;}
              .FootnoteData {color: green; background-color: white; font-size: x-small; font-family: Times, serif;}
              .FormNumText {font-size: small; font-weight: bold; font-family: arial, helvetica, sans-serif;}
              .FormAttention {font-size: medium; font-weight: bold; font-family: helvetica;}
              .FormText {font-size: small; font-weight: normal; font-family: arial, helvetica, sans-serif; text-align: left;}
              .FormTextR {font-size: small; font-weight: normal; font-family: arial, helvetica, sans-serif; text-align: right;}
              .FormTextC {font-size: small; font-weight: normal; font-family: arial, helvetica, sans-serif; text-align: center;}
              .FormEMText {font-size: medium; font-style: italic; font-weight: normal; font-family: arial, helvetica, sans-serif;}
              .FormULText {font-size: medium; text-decoration: underline; font-weight: normal; font-family: arial, helvetica, sans-serif;}
              .SmallFormText {font-size: xx-small; font-family: arial, helvetica, sans-serif; text-align: left;}
              .SmallFormTextR {font-size: xx-small; font-family: arial, helvetica, sans-serif; text-align: right;}
              .SmallFormTextC {font-size: xx-small; font-family: arial, helvetica, sans-serif; text-align: center;}
              .MedSmallFormText {font-size: x-small; font-family: arial, helvetica, sans-serif; text-align: left;}
              .FormTitle {font-size: medium; font-family: arial, helvetica, sans-serif; font-weight: bold;}
              .FormTitle1 {font-size: small; font-family: arial, helvetica, sans-serif; font-weight: bold; border-top: black thick solid;}
              .FormTitle2 {font-size: small; font-family: arial, helvetica, sans-serif; font-weight: bold;}
              .FormTitle3 {font-size: small; font-family: arial, helvetica, sans-serif; font-weight: bold; padding-top: 2em; padding-bottom: 1em;}
              .SectionTitle {font-size: small; text-align: left; font-family: arial, helvetica, sans-serif; 
              		font-weight: bold; border-top: gray thin solid; border-bottom: gray thin solid;}
              .FormName {font-size: large; font-family: arial, helvetica, sans-serif; font-weight: bold;}
              .CheckBox {text-align: center; width: 5px; cell-spacing: 0; padding: 0 3 0 3; border-width: thin; border-style: solid;  border-color: black:}
              body {background: white;}
      </style>
</head>
<body>SEC Form 4 
   <table width="100%" border="0" cellspacing="0" cellpadding="4">
<tr>
<td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 4</td>
<td rowspan="2" width="60%" valign="middle" align="center">
<span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span>
</td>
<td rowspan="2" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box">
<tr><td class="FormTextC">OMB APPROVAL</td></tr>
<tr><td><table width="100%" border="0" summary="OMB Interior Box">
<tr>
<td class="SmallFormText" colspan="3">OMB Number:</td>
<td class="SmallFormTextR">3235-0287</td>
</tr>
<tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr>
<tr>
<td class="SmallFormText" colspan="3">hours per response:</td>
<td class="SmallFormTextR">0.5</td>
</tr>
</table></td></tr>
</table></td>
</tr>
<tr valign="middle">
<td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td>
<td class="SmallFormText">Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 
         <i>See</i>

         Instruction 1(b).</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<tr>
<td rowspan="3" width="35%" valign="top">
<span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001207792">MORE ROBERT J</a></td></tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(Last)</td>
<td width="33%" class="MedSmallFormText">(First)</td>
<td width="33%" class="MedSmallFormText">(Middle)</td>
</tr></table>
<table border="0" width="100%">
<tr><td><span class="FormData">C/O VIR BIOTECHNOLOGY, INC.</span></td></tr>
<tr><td><span class="FormData">499 ILLINOIS STREET, SUITE 500</span></td></tr>
</table>
<hr width="98%">
<span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr>
<td width="33%"><span class="FormData">SAN FRANCISCO</span></td>
<td width="33%"><span class="FormData">CA</span></td>
<td width="33%"><span class="FormData">94158</span></td>
</tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(City)</td>
<td width="33%" class="MedSmallFormText">(State)</td>
<td width="33%" class="MedSmallFormText">(Zip)</td>
</tr></table>
</td>
<td width="35%" valign="top">
<span class="MedSmallFormText">2. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001706431">Vir Biotechnology, Inc.</a>
     [ <span class="FormData">VIR</span> ]
   </td>
<td rowspan="2" valign="top">
<span class="MedSmallFormText">5. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="35%" class="MedSmallFormText">Director</td>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">10% Owner</td>
</tr>
<tr>
<td align="center"></td>
<td class="MedSmallFormText">Officer (give title below)</td>
<td align="center"></td>
<td class="MedSmallFormText">Other (specify below)</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
</tr>
</table>
</td>
</tr>
<tr><td valign="top">
<span class="MedSmallFormText">3. Date of Earliest Transaction
         (Month/Day/Year)</span><br><span class="FormData">05/23/2022</span>
</td></tr>
<tr>
<td valign="top">
<span class="MedSmallFormText">4. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br>
</td>
<td valign="top">
<span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td>
</tr>
</table>
</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="11" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned</b></th></tr>
<tr>
<th width="36%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      3)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="7%" valign="top" colspan="2" align="left" class="SmallFormText">3. Transaction Code (Instr. 
      8)
   </th>
<th width="19%" valign="top" colspan="3" align="left" class="SmallFormText">4. Securities Acquired (A) or Disposed Of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="11%" valign="top" rowspan="2" align="left" class="SmallFormText">5. 
      Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      3 and 4)
   </th>
<th width="9%" valign="top" rowspan="2" align="left" class="SmallFormText">6. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="8%" valign="top" rowspan="2" align="left" class="SmallFormText">7. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" align="center" class="SmallFormText">Code</th>
<th width="3%" align="center" class="SmallFormText">V</th>
<th width="8%" align="center" class="SmallFormText">Amount</th>
<th width="5%" align="center" class="SmallFormText">(A) or (D)</th>
<th width="6%" align="center" class="SmallFormText">Price</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"><span class="FormData">05/23/2022</span></td>
<td align="center"><span class="FormData"></span></td>
<td align="center"><span class="SmallFormData">A</span></td>
<td align="center"></td>
<td align="center"><span class="FormData">6,405</span></td>
<td align="center"><span class="FormData">A</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">0.00</span>
</td>
<td align="center"><span class="FormData">42,435</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="FormData">486,111</span></td>
<td align="center"><span class="FormData">I</span></td>
<td align="left">
<span class="FormData">See footnote</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
</tr>
</tbody>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="16" align="center" class="FormTextC">
<b>Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b>
</th></tr>
<tr>
<th width="13%" valign="top" rowspan="2" align="left" class="SmallFormText">1. Title of Derivative Security (Instr. 
      3)
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Conversion or Exercise Price of Derivative Security
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">4. Transaction Code (Instr. 
      8)
   </th>
<th width="10%" valign="top" colspan="2" align="left" class="SmallFormText">5. 
      Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">6. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th>
<th width="17%" valign="top" colspan="2" align="left" class="SmallFormText">7. Title and Amount of Securities Underlying Derivative Security (Instr. 
      3 and 4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">8. Price of Derivative Security (Instr. 
      5)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">9. 
      Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">10. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="7%" valign="top" rowspan="2" align="left" class="SmallFormText">11. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Code</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">V</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(A)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(D)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">Date Exercisable</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Expiration Date</th>
<th width="10%" valign="bottom" align="center" class="SmallFormText">Title</th>
<th width="7%" valign="bottom" align="center" class="SmallFormText">Amount or Number of Shares</th>
</tr>
</thead>
<tbody><tr>
<td align="left"><span class="SmallFormData">Stock Option (Right to Buy)</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">24.14</span>
</td>
<td align="center"><span class="SmallFormData">05/23/2022</span></td>
<td align="center"><span class="SmallFormData"></span></td>
<td align="center"><span class="SmallFormData">A</span></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">12,810</span></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">05/23/2023</span></td>
<td align="center"><span class="SmallFormData">05/22/2032</span></td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">12,810</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0.00</span>
</td>
<td align="center"><span class="SmallFormData">12,810</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr></tbody>
</table>
<table border="0" width="100%">
<tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr>
<tr><td class="FootnoteData">1. The shares are held by Alta Partners NextGen Fund I, L.P. (APNG 1). The reporting person is a managing director of Alta Partners NextGen Fund I Management, LLC, which is the general partner of APNG 1. As such, the reporting person may be deemed to beneficially own the shares held by APNG 1. However, the reporting person disclaims beneficial ownership of such securities, except to the extent of his pecuniary interest therein, and this report shall not be deemed to be an admission that the reporting person is the beneficial owner of such securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise.</td></tr>
<tr><td class="FormText"><b>Remarks:</b></td></tr>
<tr><td class="FootnoteData"></td></tr>
</table>
<table width="100%" border="0">
<tr>
<td width="60%"></td>
<td width="20%"><u><span class="FormData">/s/ Howard Horn, Attorney-in-Fact</span></u></td>
<td width="20%"><u><span class="FormData">05/25/2022</span></u></td>
</tr>
<tr>
<td></td>
<td class="MedSmallFormText">** Signature of Reporting Person</td>
<td class="MedSmallFormText">Date</td>
</tr>
<tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr>
<tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  4

                  (b)(v).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr>
<tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr>
</table>
</body>
</html>
