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<title>SEC FORM 
            4</title>
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<body>SEC Form 4 
   <table width="100%" border="0" cellspacing="0" cellpadding="4">
<tr>
<td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 4</td>
<td rowspan="2" width="60%" valign="middle" align="center">
<span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span>
</td>
<td rowspan="2" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box">
<tr><td class="FormTextC">OMB APPROVAL</td></tr>
<tr><td><table width="100%" border="0" summary="OMB Interior Box">
<tr>
<td class="SmallFormText" colspan="3">OMB Number:</td>
<td class="SmallFormTextR">3235-0287</td>
</tr>
<tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr>
<tr>
<td class="SmallFormText" colspan="3">hours per response:</td>
<td class="SmallFormTextR">0.5</td>
</tr>
</table></td></tr>
</table></td>
</tr>
<tr valign="middle">
<td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td>
<td class="SmallFormText">Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 
         <i>See</i>

         Instruction 1(b).</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<tr>
<td rowspan="3" width="35%" valign="top">
<span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001354434">Renaud Ronald C JR</a></td></tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(Last)</td>
<td width="33%" class="MedSmallFormText">(First)</td>
<td width="33%" class="MedSmallFormText">(Middle)</td>
</tr></table>
<table border="0" width="100%">
<tr><td><span class="FormData">C/O TRANSLATE BIO, INC.</span></td></tr>
<tr><td><span class="FormData">29 HARTWELL AVE</span></td></tr>
</table>
<hr width="98%">
<span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr>
<td width="33%"><span class="FormData">LEXINGTON</span></td>
<td width="33%"><span class="FormData">MA</span></td>
<td width="33%"><span class="FormData">02421</span></td>
</tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(City)</td>
<td width="33%" class="MedSmallFormText">(State)</td>
<td width="33%" class="MedSmallFormText">(Zip)</td>
</tr></table>
</td>
<td width="35%" valign="top">
<span class="MedSmallFormText">2. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001693415">Translate Bio, Inc.</a>
     [ <span class="FormData">TBIO</span> ]
   </td>
<td rowspan="2" valign="top">
<span class="MedSmallFormText">5. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="35%" class="MedSmallFormText">Director</td>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">10% Owner</td>
</tr>
<tr>
<td align="center"><span class="FormData">X</span></td>
<td class="MedSmallFormText">Officer (give title below)</td>
<td align="center"></td>
<td class="MedSmallFormText">Other (specify below)</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue">Chief Executive Officer</td>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
</tr>
</table>
</td>
</tr>
<tr><td valign="top">
<span class="MedSmallFormText">3. Date of Earliest Transaction
         (Month/Day/Year)</span><br><span class="FormData">09/14/2021</span>
</td></tr>
<tr>
<td valign="top">
<span class="MedSmallFormText">4. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br>
</td>
<td valign="top">
<span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td>
</tr>
</table>
</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="11" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned</b></th></tr>
<tr>
<th width="36%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      3)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="7%" valign="top" colspan="2" align="left" class="SmallFormText">3. Transaction Code (Instr. 
      8)
   </th>
<th width="19%" valign="top" colspan="3" align="left" class="SmallFormText">4. Securities Acquired (A) or Disposed Of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="11%" valign="top" rowspan="2" align="left" class="SmallFormText">5. 
      Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      3 and 4)
   </th>
<th width="9%" valign="top" rowspan="2" align="left" class="SmallFormText">6. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="8%" valign="top" rowspan="2" align="left" class="SmallFormText">7. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" align="center" class="SmallFormText">Code</th>
<th width="3%" align="center" class="SmallFormText">V</th>
<th width="8%" align="center" class="SmallFormText">Amount</th>
<th width="5%" align="center" class="SmallFormText">(A) or (D)</th>
<th width="6%" align="center" class="SmallFormText">Price</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center">
<span class="FormData">09/14/2021</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="FormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"></td>
<td align="center"><span class="FormData">503,231</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">38</span>
</td>
<td align="center"><span class="FormData">0</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center">
<span class="FormData">09/14/2021</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="FormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"></td>
<td align="center"><span class="FormData">409,913</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">38</span>
</td>
<td align="center"><span class="FormData">0</span></td>
<td align="center"><span class="FormData">I</span></td>
<td align="left"><span class="FormData">By Ronald Renaud 2014 Irrevocable Family Trust</span></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center">
<span class="FormData">09/14/2021</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="FormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"></td>
<td align="center"><span class="FormData">40,909</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">38</span>
</td>
<td align="center"><span class="FormData">0</span></td>
<td align="center"><span class="FormData">I</span></td>
<td align="left"><span class="FormData">By Ronald C. Renaud, Jr. Trust - 2007</span></td>
</tr>
</tbody>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="16" align="center" class="FormTextC">
<b>Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b>
</th></tr>
<tr>
<th width="13%" valign="top" rowspan="2" align="left" class="SmallFormText">1. Title of Derivative Security (Instr. 
      3)
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Conversion or Exercise Price of Derivative Security
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">4. Transaction Code (Instr. 
      8)
   </th>
<th width="10%" valign="top" colspan="2" align="left" class="SmallFormText">5. 
      Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">6. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th>
<th width="17%" valign="top" colspan="2" align="left" class="SmallFormText">7. Title and Amount of Securities Underlying Derivative Security (Instr. 
      3 and 4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">8. Price of Derivative Security (Instr. 
      5)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">9. 
      Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">10. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="7%" valign="top" rowspan="2" align="left" class="SmallFormText">11. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Code</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">V</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(A)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(D)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">Date Exercisable</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Expiration Date</th>
<th width="10%" valign="bottom" align="center" class="SmallFormText">Title</th>
<th width="7%" valign="bottom" align="center" class="SmallFormText">Amount or Number of Shares</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left"><span class="SmallFormData">Stock Option (right to buy)</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">7.95</span>
</td>
<td align="center"><span class="SmallFormData">09/14/2021</span></td>
<td align="center"><span class="SmallFormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">500,000</span></td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(3)</sup></span>
</td>
<td align="center"><span class="SmallFormData">03/07/2029</span></td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">500,000</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0.00</span>
</td>
<td align="center"><span class="SmallFormData">0</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="SmallFormData">Stock Option (right to buy)</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">7.66</span>
</td>
<td align="center"><span class="SmallFormData">09/14/2021</span></td>
<td align="center"><span class="SmallFormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">525,000</span></td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(4)</sup></span>
</td>
<td align="center"><span class="SmallFormData">03/02/2030</span></td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">525,000</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0.00</span>
</td>
<td align="center"><span class="SmallFormData">0</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="SmallFormData">Stcok Option (right to buy)</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">23.82</span>
</td>
<td align="center"><span class="SmallFormData">09/14/2021</span></td>
<td align="center"><span class="SmallFormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">325,000</span></td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(5)</sup></span>
</td>
<td align="center"><span class="SmallFormData">03/09/2031</span></td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">325,000</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0.00</span>
</td>
<td align="center"><span class="SmallFormData">0</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="SmallFormData">Stock Option (right to buy)</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">7.39</span>
</td>
<td align="center"><span class="SmallFormData">09/14/2021</span></td>
<td align="center"><span class="SmallFormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">1,071,009</span></td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(6)</sup></span>
</td>
<td align="center"><span class="SmallFormData">12/21/2027</span></td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">1,071,009</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0.00</span>
</td>
<td align="center"><span class="SmallFormData">0</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="SmallFormData">Stock Option (right to buy)</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">8.34</span>
</td>
<td align="center"><span class="SmallFormData">09/14/2021</span></td>
<td align="center"><span class="SmallFormData"></span></td>
<td align="center">
<span class="SmallFormData">S</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">89,996</span></td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(7)</sup></span>
</td>
<td align="center"><span class="SmallFormData">03/06/2028</span></td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">89,996</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0.00</span>
</td>
<td align="center"><span class="SmallFormData">0</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr>
</tbody>
</table>
<table border="0" width="100%">
<tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr>
<tr><td class="FootnoteData">1. As of September 14, 2021, Issuer was acquired in a cash tender by an indirect subsidiary of Sanofi, a French societe anonyme at a purchase price of $38.00 per share (the "Tender Offer"), as described more fully in the Schedule 14D-9 filed by the Issuer on August 16, 2021.</td></tr>
<tr><td class="FootnoteData">2. Under the terms of the Tender Offer, Issuer outstanding stock options, if not vested became vested, and all Issuer stock options were converted into cash consideration at the amount of the difference between the exercise price of the option and the Tender Offer price of $38.00 per share.</td></tr>
<tr><td class="FootnoteData">3. This option was granted on March 8, 2019. This option will vest as to 25% of the shares on March 8, 2020, and in thirty-six equal monthly installments thereafter as to the remaining shares through March 8, 2023.</td></tr>
<tr><td class="FootnoteData">4. This option was granted on March 3, 2020. This option will vest as to 25% of the shares on March 3, 2021, and in thirty-six equal monthly installments thereafter as to the remaining shares through March 3, 2024.</td></tr>
<tr><td class="FootnoteData">5. This option was granted on March 9, 2021. This option will vest as to 25% of the shares on March 9, 2022, and in thirty-six equal monthly installments thereafter as to the remaining shares through March 9, 2025.</td></tr>
<tr><td class="FootnoteData">6. This option was granted on December 22, 2017.  The shares underlying became fully vested on March 9, 2021.</td></tr>
<tr><td class="FootnoteData">7. This option was granted on March 7, 2018.  The shares underlying the option are scheduled to vest over four years, with 25% of the shares vesting on March 7, 2019 and the remainder vesting in equal monthly installment through March 7, 2022.</td></tr>
<tr><td class="FormText"><b>Remarks:</b></td></tr>
<tr><td class="FootnoteData"></td></tr>
</table>
<table width="100%" border="0">
<tr>
<td width="60%"></td>
<td width="20%"><u><span class="FormData">/s/ Paul D. Burgess, as attorney-in-fact for Ronald C. Renaud, Jr.</span></u></td>
<td width="20%"><u><span class="FormData">09/14/2021</span></u></td>
</tr>
<tr>
<td></td>
<td class="MedSmallFormText">** Signature of Reporting Person</td>
<td class="MedSmallFormText">Date</td>
</tr>
<tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr>
<tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  4

                  (b)(v).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr>
<tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr>
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