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<title>SEC FORM 
            4</title>
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<body>SEC Form 4 
   <table width="100%" border="0" cellspacing="0" cellpadding="4">
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<td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 4</td>
<td rowspan="2" width="60%" valign="middle" align="center">
<span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span>
</td>
<td rowspan="2" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box">
<tr><td class="FormTextC">OMB APPROVAL</td></tr>
<tr><td><table width="100%" border="0" summary="OMB Interior Box">
<tr>
<td class="SmallFormText" colspan="3">OMB Number:</td>
<td class="SmallFormTextR">3235-0287</td>
</tr>
<tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr>
<tr>
<td class="SmallFormText" colspan="3">hours per response:</td>
<td class="SmallFormTextR">0.5</td>
</tr>
</table></td></tr>
</table></td>
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<tr valign="middle">
<td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td>
<td class="SmallFormText">Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 
         <i>See</i>

         Instruction 1(b).</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<tr>
<td rowspan="3" width="35%" valign="top">
<span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001121404">Sanofi</a></td></tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(Last)</td>
<td width="33%" class="MedSmallFormText">(First)</td>
<td width="33%" class="MedSmallFormText">(Middle)</td>
</tr></table>
<table border="0" width="100%">
<tr><td><span class="FormData">54, RUE LA BOETIE</span></td></tr>
<tr><td><span class="FormData"></span></td></tr>
</table>
<hr width="98%">
<span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr>
<td width="33%"><span class="FormData">PARIS</span></td>
<td width="33%"><span class="FormData">I0</span></td>
<td width="33%"><span class="FormData">75008</span></td>
</tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(City)</td>
<td width="33%" class="MedSmallFormText">(State)</td>
<td width="33%" class="MedSmallFormText">(Zip)</td>
</tr></table>
</td>
<td width="35%" valign="top">
<span class="MedSmallFormText">2. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001693415">Translate Bio, Inc.</a>
     [ <span class="FormData">TBIO</span> ]
   </td>
<td rowspan="2" valign="top">
<span class="MedSmallFormText">5. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%">
<tr>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">Director</td>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="35%" class="MedSmallFormText">10% Owner</td>
</tr>
<tr>
<td align="center"></td>
<td class="MedSmallFormText">Officer (give title below)</td>
<td align="center"></td>
<td class="MedSmallFormText">Other (specify below)</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
</tr>
</table>
</td>
</tr>
<tr><td valign="top">
<span class="MedSmallFormText">3. Date of Earliest Transaction
         (Month/Day/Year)</span><br><span class="FormData">09/14/2021</span>
</td></tr>
<tr>
<td valign="top">
<span class="MedSmallFormText">4. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br>
</td>
<td valign="top">
<span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td>
</tr>
</table>
</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="11" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned</b></th></tr>
<tr>
<th width="36%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      3)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="7%" valign="top" colspan="2" align="left" class="SmallFormText">3. Transaction Code (Instr. 
      8)
   </th>
<th width="19%" valign="top" colspan="3" align="left" class="SmallFormText">4. Securities Acquired (A) or Disposed Of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="11%" valign="top" rowspan="2" align="left" class="SmallFormText">5. 
      Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      3 and 4)
   </th>
<th width="9%" valign="top" rowspan="2" align="left" class="SmallFormText">6. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="8%" valign="top" rowspan="2" align="left" class="SmallFormText">7. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" align="center" class="SmallFormText">Code</th>
<th width="3%" align="center" class="SmallFormText">V</th>
<th width="8%" align="center" class="SmallFormText">Amount</th>
<th width="5%" align="center" class="SmallFormText">(A) or (D)</th>
<th width="6%" align="center" class="SmallFormText">Price</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left"><span class="FormData">Common Stock, par value $0.001 per share</span></td>
<td align="center"><span class="FormData">09/14/2021</span></td>
<td align="center"><span class="FormData"></span></td>
<td align="center"><span class="SmallFormData">P</span></td>
<td align="center"></td>
<td align="center">
<span class="FormData">51,467,612</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="FormData">A</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">38</span>
</td>
<td align="center"><span class="FormData">55,152,046</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock, par value $0.001 per share</span></td>
<td align="center"><span class="FormData">09/14/2021</span></td>
<td align="center"><span class="FormData"></span></td>
<td align="center"><span class="SmallFormData">P</span></td>
<td align="center"></td>
<td align="center">
<span class="FormData">20,515,985</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"><span class="FormData">A</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">38</span>
</td>
<td align="center">
<span class="FormData">75,668,031</span><span class="FootnoteData"><sup>(3)</sup></span>
</td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
</tbody>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4"><thead>
<tr><th width="100%" valign="top" colspan="16" align="center" class="FormTextC">
<b>Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b>
</th></tr>
<tr>
<th width="13%" valign="top" rowspan="2" align="left" class="SmallFormText">1. Title of Derivative Security (Instr. 
      3)
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Conversion or Exercise Price of Derivative Security
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">4. Transaction Code (Instr. 
      8)
   </th>
<th width="10%" valign="top" colspan="2" align="left" class="SmallFormText">5. 
      Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">6. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th>
<th width="17%" valign="top" colspan="2" align="left" class="SmallFormText">7. Title and Amount of Securities Underlying Derivative Security (Instr. 
      3 and 4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">8. Price of Derivative Security (Instr. 
      5)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">9. 
      Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">10. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="7%" valign="top" rowspan="2" align="left" class="SmallFormText">11. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Code</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">V</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(A)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(D)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">Date Exercisable</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Expiration Date</th>
<th width="10%" valign="bottom" align="center" class="SmallFormText">Title</th>
<th width="7%" valign="bottom" align="center" class="SmallFormText">Amount or Number of Shares</th>
</tr>
</thead></table>
<table border="0" width="100%">
<tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr>
<tr><td class="FootnoteData">1. Shares of Common Stock, par value $0.001 per share (the "Shares"), of Translate Bio, Inc. ("Translate Bio") acquired by Sanofi and its wholly-owned subsidiaries pursuant to the tender offer effected pursuant to the Agreement and Plan of Merger, dated as of August 2, 2021 (the "Merger Agreement"), by and among Sanofi, Vector Merger Sub, Inc., an indirect, wholly owned subsidiary of Sanofi ("Merger Sub"), and Translate Bio (such tender offer, the "Offer"). Prior to the Offer, Sanofi beneficially owned 3,684,434 Shares (approximately 4.87%).</td></tr>
<tr><td class="FootnoteData">2. Reflects all of the outstanding Shares not tendered in the Offer and not owned by Sanofi or its wholly-owned subsidiaries prior to the Offer, which may be deemed to have been acquired pursuant to the consummation of the Merger (as defined below). Pursuant to the Merger, Sanofi now beneficially owns all outstanding Shares.</td></tr>
<tr><td class="FootnoteData">3. Following the consummation of the Offer, Merger Sub was merged with and into Translate Bio, and Translate Bio survived the Merger as an indirect, wholly-owned subsidiary of Sanofi pursuant to a "back-end merger" under Delaware law (the "Merger"). Prior to the Merger, Sanofi indirectly held 100 shares of Merger Sub, which represented all of the issued and outstanding capital stock of Merger Sub. At the effective time of the Merger, all of the shares of Merger Sub were converted into 71,983,597 shares of Translate Bio stock.</td></tr>
<tr><td class="FormText"><b>Remarks:</b></td></tr>
<tr><td class="FootnoteData"></td></tr>
</table>
<table width="100%" border="0">
<tr>
<td width="60%"></td>
<td width="20%"><u><span class="FormData">/s/ Alexandra Roger, as Head of Securities Law and Capital Markets of Sanofi</span></u></td>
<td width="20%"><u><span class="FormData">09/14/2021</span></u></td>
</tr>
<tr>
<td></td>
<td class="MedSmallFormText">** Signature of Reporting Person</td>
<td class="MedSmallFormText">Date</td>
</tr>
<tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr>
<tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  4

                  (b)(v).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr>
<tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr>
</table>
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