<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd">
<html>
<head>
<meta http-equiv="Content-Type" content="text/html; charset=UTF-8">
<title>SEC FORM 
            4</title>
<style type="text/css">
              .FormData {color: blue; background-color: white; font-size: small; font-family: Times, serif;}
              .FormDataC {color: blue; background-color: white; font-size: small; font-family: Times, serif; text-align: center;}
              .FormDataR {color: blue; background-color: white; font-size: small; font-family: Times, serif; text-align: right;}
              .SmallFormData {color: blue; background-color: white; font-size: x-small; font-family: Times, serif;}
              .FootnoteData {color: green; background-color: white; font-size: x-small; font-family: Times, serif;}
              .FormNumText {font-size: small; font-weight: bold; font-family: arial, helvetica, sans-serif;}
              .FormAttention {font-size: medium; font-weight: bold; font-family: helvetica;}
              .FormText {font-size: small; font-weight: normal; font-family: arial, helvetica, sans-serif; text-align: left;}
              .FormTextR {font-size: small; font-weight: normal; font-family: arial, helvetica, sans-serif; text-align: right;}
              .FormTextC {font-size: small; font-weight: normal; font-family: arial, helvetica, sans-serif; text-align: center;}
              .FormEMText {font-size: medium; font-style: italic; font-weight: normal; font-family: arial, helvetica, sans-serif;}
              .FormULText {font-size: medium; text-decoration: underline; font-weight: normal; font-family: arial, helvetica, sans-serif;}
              .SmallFormText {font-size: xx-small; font-family: arial, helvetica, sans-serif; text-align: left;}
              .SmallFormTextR {font-size: xx-small; font-family: arial, helvetica, sans-serif; text-align: right;}
              .SmallFormTextC {font-size: xx-small; font-family: arial, helvetica, sans-serif; text-align: center;}
              .MedSmallFormText {font-size: x-small; font-family: arial, helvetica, sans-serif; text-align: left;}
              .FormTitle {font-size: medium; font-family: arial, helvetica, sans-serif; font-weight: bold;}
              .FormTitle1 {font-size: small; font-family: arial, helvetica, sans-serif; font-weight: bold; border-top: black thick solid;}
              .FormTitle2 {font-size: small; font-family: arial, helvetica, sans-serif; font-weight: bold;}
              .FormTitle3 {font-size: small; font-family: arial, helvetica, sans-serif; font-weight: bold; padding-top: 2em; padding-bottom: 1em;}
              .SectionTitle {font-size: small; text-align: left; font-family: arial, helvetica, sans-serif; 
              		font-weight: bold; border-top: gray thin solid; border-bottom: gray thin solid;}
              .FormName {font-size: large; font-family: arial, helvetica, sans-serif; font-weight: bold;}
              .CheckBox {text-align: center; width: 5px; cell-spacing: 0; padding: 0 3 0 3; border-width: thin; border-style: solid;  border-color: black:}
              body {background: white;}
      </style>
</head>
<body>SEC Form 4 
   <table width="100%" border="0" cellspacing="0" cellpadding="4">
<tr>
<td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 4</td>
<td rowspan="2" width="60%" valign="middle" align="center">
<span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span>
</td>
<td rowspan="2" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box">
<tr><td class="FormTextC">OMB APPROVAL</td></tr>
<tr><td><table width="100%" border="0" summary="OMB Interior Box">
<tr>
<td class="SmallFormText" colspan="3">OMB Number:</td>
<td class="SmallFormTextR">3235-0287</td>
</tr>
<tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr>
<tr>
<td class="SmallFormText" colspan="3">hours per response:</td>
<td class="SmallFormTextR">0.5</td>
</tr>
</table></td></tr>
</table></td>
</tr>
<tr valign="middle">
<td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td>
<td class="SmallFormText">Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 
         <i>See</i>

         Instruction 1(b).</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<tr>
<td rowspan="3" width="35%" valign="top">
<span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001470981">Ji Henry</a></td></tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(Last)</td>
<td width="33%" class="MedSmallFormText">(First)</td>
<td width="33%" class="MedSmallFormText">(Middle)</td>
</tr></table>
<table border="0" width="100%">
<tr><td><span class="FormData">C/O SORRENTO THERAPEUTICS, INC.</span></td></tr>
<tr><td><span class="FormData">4955 DIRECTORS PLACE</span></td></tr>
</table>
<hr width="98%">
<span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr>
<td width="33%"><span class="FormData">SAN DIEGO</span></td>
<td width="33%"><span class="FormData">CA</span></td>
<td width="33%"><span class="FormData">92121</span></td>
</tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(City)</td>
<td width="33%" class="MedSmallFormText">(State)</td>
<td width="33%" class="MedSmallFormText">(Zip)</td>
</tr></table>
</td>
<td width="35%" valign="top">
<span class="MedSmallFormText">2. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0000850261">Sorrento Therapeutics, Inc.</a>
     [ <span class="FormData">SRNE</span> ]
   </td>
<td rowspan="2" valign="top">
<span class="MedSmallFormText">5. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="35%" class="MedSmallFormText">Director</td>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">10% Owner</td>
</tr>
<tr>
<td align="center"><span class="FormData">X</span></td>
<td class="MedSmallFormText">Officer (give title below)</td>
<td align="center"></td>
<td class="MedSmallFormText">Other (specify below)</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue">See Remarks</td>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
</tr>
</table>
</td>
</tr>
<tr><td valign="top">
<span class="MedSmallFormText">3. Date of Earliest Transaction
         (Month/Day/Year)</span><br><span class="FormData">12/15/2022</span>
</td></tr>
<tr>
<td valign="top">
<span class="MedSmallFormText">4. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br>
</td>
<td valign="top">
<span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td>
</tr>
</table>
</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="11" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned</b></th></tr>
<tr>
<th width="36%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      3)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="7%" valign="top" colspan="2" align="left" class="SmallFormText">3. Transaction Code (Instr. 
      8)
   </th>
<th width="19%" valign="top" colspan="3" align="left" class="SmallFormText">4. Securities Acquired (A) or Disposed Of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="11%" valign="top" rowspan="2" align="left" class="SmallFormText">5. 
      Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      3 and 4)
   </th>
<th width="9%" valign="top" rowspan="2" align="left" class="SmallFormText">6. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="8%" valign="top" rowspan="2" align="left" class="SmallFormText">7. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" align="center" class="SmallFormText">Code</th>
<th width="3%" align="center" class="SmallFormText">V</th>
<th width="8%" align="center" class="SmallFormText">Amount</th>
<th width="5%" align="center" class="SmallFormText">(A) or (D)</th>
<th width="6%" align="center" class="SmallFormText">Price</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center">
<span class="FormData">12/15/2022</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="FormData"></span></td>
<td align="center"><span class="SmallFormData">A</span></td>
<td align="center"></td>
<td align="center">
<span class="FormData">1,500,000</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"><span class="FormData">A</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">0.00</span>
</td>
<td align="center"><span class="FormData">6,265,805</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="FormData">2,271,693</span></td>
<td align="center"><span class="FormData">I</span></td>
<td align="left">
<span class="FormData">See Footnote</span><span class="FootnoteData"><sup>(3)</sup></span>
</td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="FormData">40,000</span></td>
<td align="center"><span class="FormData">I</span></td>
<td align="left"><span class="FormData">By spouse</span></td>
</tr>
</tbody>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4"><thead>
<tr><th width="100%" valign="top" colspan="16" align="center" class="FormTextC">
<b>Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b>
</th></tr>
<tr>
<th width="13%" valign="top" rowspan="2" align="left" class="SmallFormText">1. Title of Derivative Security (Instr. 
      3)
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Conversion or Exercise Price of Derivative Security
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">4. Transaction Code (Instr. 
      8)
   </th>
<th width="10%" valign="top" colspan="2" align="left" class="SmallFormText">5. 
      Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">6. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th>
<th width="17%" valign="top" colspan="2" align="left" class="SmallFormText">7. Title and Amount of Securities Underlying Derivative Security (Instr. 
      3 and 4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">8. Price of Derivative Security (Instr. 
      5)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">9. 
      Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">10. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="7%" valign="top" rowspan="2" align="left" class="SmallFormText">11. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Code</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">V</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(A)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(D)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">Date Exercisable</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Expiration Date</th>
<th width="10%" valign="bottom" align="center" class="SmallFormText">Title</th>
<th width="7%" valign="bottom" align="center" class="SmallFormText">Amount or Number of Shares</th>
</tr>
</thead></table>
<table border="0" width="100%">
<tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr>
<tr><td class="FootnoteData">1. The grant to the Reporting Person of a restricted stock unit award for 1,500,000 shares of the Issuer's common stock (the "RSU Award") was approved by the compensation committee of the board of directors of the Issuer on September 1, 2022 and was granted to the Reporting Person on September 2, 2022. The RSU Award was conditioned upon and subject to the Issuer's stockholders approving an amendment to the Issuer's 2019 Stock Incentive Plan to increase the number of shares authorized for issuance thereunder (the "Plan Amendment"). The Issuer's stockholders approved the Plan Amendment on December 15, 2022.</td></tr>
<tr><td class="FootnoteData">2. The reported securities are shares subject to the RSU Award. 1/4th of the shares subject to the RSU Award shall vest on September 2, 2023 and 1/4th of the shares
subject to the RSU Award shall vest on each anniversary thereafter.</td></tr>
<tr><td class="FootnoteData">3. Shares are held in family trusts of which the Reporting Person is a co-trustee with his spouse.</td></tr>
<tr><td class="FormText"><b>Remarks:</b></td></tr>
<tr><td class="FootnoteData">President, CEO and Chairman of the Board of Directors</td></tr>
</table>
<table width="100%" border="0">
<tr>
<td width="60%"></td>
<td width="20%"><u><span class="FormData">/s/ Henry Ji, Ph.D.</span></u></td>
<td width="20%"><u><span class="FormData">12/16/2022</span></u></td>
</tr>
<tr>
<td></td>
<td class="MedSmallFormText">** Signature of Reporting Person</td>
<td class="MedSmallFormText">Date</td>
</tr>
<tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr>
<tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  4

                  (b)(v).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr>
<tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr>
</table>
</body>
</html>
