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<title>SEC FORM 
            4</title>
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<body>SEC Form 4 
   <table width="100%" border="0" cellspacing="0" cellpadding="4">
<tr>
<td width="20%" colspan="2" valign="top" align="center" class="FormName">FORM 4</td>
<td rowspan="2" width="60%" valign="middle" align="center">
<span class="FormTitle">UNITED STATES SECURITIES AND EXCHANGE COMMISSION</span><br><span class="MedSmallFormText">Washington, D.C. 20549</span><br><br><span class="FormTitle">STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP</span><br><br><span class="MedSmallFormText">Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934</span><br><span class="MedSmallFormText">or Section 30(h) of the Investment Company Act of 1940</span>
</td>
<td rowspan="2" width="20%" valign="top" align="center"><table width="100%" border="1" summary="OMB Approval Status Box">
<tr><td class="FormTextC">OMB APPROVAL</td></tr>
<tr><td><table width="100%" border="0" summary="OMB Interior Box">
<tr>
<td class="SmallFormText" colspan="3">OMB Number:</td>
<td class="SmallFormTextR">3235-0287</td>
</tr>
<tr><td class="SmallFormText" colspan="4">Estimated average burden</td></tr>
<tr>
<td class="SmallFormText" colspan="3">hours per response:</td>
<td class="SmallFormTextR">0.5</td>
</tr>
</table></td></tr>
</table></td>
</tr>
<tr valign="middle">
<td><table width="100%" border="1" cellpadding="0" cellspacing="0"><tr><td>  </td></tr></table></td>
<td class="SmallFormText">Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. 
         <i>See</i>

         Instruction 1(b).</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<tr>
<td rowspan="3" width="35%" valign="top">
<span class="MedSmallFormText">1. Name and Address of Reporting Person<sup>*</sup></span><table border="0" width="100%"><tr><td><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001259780">KIES PETER</a></td></tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(Last)</td>
<td width="33%" class="MedSmallFormText">(First)</td>
<td width="33%" class="MedSmallFormText">(Middle)</td>
</tr></table>
<table border="0" width="100%">
<tr><td><span class="FormData">C/O INOVIO PHARMACEUTICALS, INC.</span></td></tr>
<tr><td><span class="FormData">6769 MESA RIDGE ROAD</span></td></tr>
</table>
<hr width="98%">
<span class="MedSmallFormText">(Street)</span><table border="0" width="100%"><tr>
<td width="33%"><span class="FormData">SAN DIEGO</span></td>
<td width="33%"><span class="FormData">CA</span></td>
<td width="33%"><span class="FormData">92121</span></td>
</tr></table>
<hr width="98%">
<table border="0" width="100%"><tr>
<td width="33%" class="MedSmallFormText">(City)</td>
<td width="33%" class="MedSmallFormText">(State)</td>
<td width="33%" class="MedSmallFormText">(Zip)</td>
</tr></table>
</td>
<td width="35%" valign="top">
<span class="MedSmallFormText">2. Issuer Name <b>and</b> Ticker or Trading Symbol
      </span><br><a href="/cgi-bin/browse-edgar?action=getcompany&amp;CIK=0001055726">INOVIO PHARMACEUTICALS, INC.</a>
     [ <span class="FormData">INO</span> ]
   </td>
<td rowspan="2" valign="top">
<span class="MedSmallFormText">5. Relationship of Reporting Person(s) to Issuer
      </span><br><span class="MedSmallFormText">(Check all applicable)</span><table border="0" width="100%">
<tr>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">Director</td>
<td width="15%" align="center"></td>
<td width="35%" class="MedSmallFormText">10% Owner</td>
</tr>
<tr>
<td align="center"><span class="FormData">X</span></td>
<td class="MedSmallFormText">Officer (give title below)</td>
<td align="center"></td>
<td class="MedSmallFormText">Other (specify below)</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue">CFO</td>
<td width="15%" align="center"></td>
<td width="35%" align="left" style="color: blue"></td>
</tr>
</table>
</td>
</tr>
<tr><td valign="top">
<span class="MedSmallFormText">3. Date of Earliest Transaction
         (Month/Day/Year)</span><br><span class="FormData">03/05/2021</span>
</td></tr>
<tr>
<td valign="top">
<span class="MedSmallFormText">4. If Amendment, Date of Original Filed
         (Month/Day/Year)</span><br>
</td>
<td valign="top">
<span class="MedSmallFormText">6. Individual or Joint/Group Filing (Check Applicable Line)
      </span><table border="0" width="100%">
<tr>
<td width="15%" align="center"><span class="FormData">X</span></td>
<td width="85%" class="MedSmallFormText">Form filed by One Reporting Person</td>
</tr>
<tr>
<td width="15%" align="center"></td>
<td width="85%" class="MedSmallFormText">Form filed by More than One Reporting Person</td>
</tr>
</table>
</td>
</tr>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="11" align="center" class="FormTextC"><b>Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned</b></th></tr>
<tr>
<th width="36%" valign="top" rowspan="2" align="left" class="MedSmallFormText">1. Title of Security (Instr. 
      3)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="7%" valign="top" colspan="2" align="left" class="SmallFormText">3. Transaction Code (Instr. 
      8)
   </th>
<th width="19%" valign="top" colspan="3" align="left" class="SmallFormText">4. Securities Acquired (A) or Disposed Of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="11%" valign="top" rowspan="2" align="left" class="SmallFormText">5. 
      Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      3 and 4)
   </th>
<th width="9%" valign="top" rowspan="2" align="left" class="SmallFormText">6. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="8%" valign="top" rowspan="2" align="left" class="SmallFormText">7. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" align="center" class="SmallFormText">Code</th>
<th width="3%" align="center" class="SmallFormText">V</th>
<th width="8%" align="center" class="SmallFormText">Amount</th>
<th width="5%" align="center" class="SmallFormText">(A) or (D)</th>
<th width="6%" align="center" class="SmallFormText">Price</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"><span class="FormData">03/05/2021</span></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">M</span></td>
<td align="center"></td>
<td align="center"><span class="FormData">27,566</span></td>
<td align="center"><span class="FormData">A</span></td>
<td align="center"><span class="FootnoteData"><sup>(1)</sup></span></td>
<td align="center"><span class="FormData">146,856</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"><span class="FormData">03/05/2021</span></td>
<td align="center"></td>
<td align="center">
<span class="SmallFormData">F</span><span class="FootnoteData"><sup>(2)</sup></span>
</td>
<td align="center"></td>
<td align="center"><span class="FormData">14,574</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">9.19</span>
</td>
<td align="center"><span class="FormData">132,282</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"><span class="FormData">03/08/2021</span></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">M</span></td>
<td align="center"></td>
<td align="center"><span class="FormData">21,467</span></td>
<td align="center"><span class="FormData">A</span></td>
<td align="center"><span class="FootnoteData"><sup>(3)</sup></span></td>
<td align="center"><span class="FormData">153,749</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"><span class="FormData">03/08/2021</span></td>
<td align="center"></td>
<td align="center">
<span class="SmallFormData">F</span><span class="FootnoteData"><sup>(4)</sup></span>
</td>
<td align="center"></td>
<td align="center"><span class="FormData">11,288</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="center">
<span class="FormText">$</span><span class="FormData">8.91</span>
</td>
<td align="center"><span class="FormData">142,461</span></td>
<td align="center"><span class="FormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="FormData">Common Stock</span></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="FormData">4,500</span></td>
<td align="center"><span class="FormData">I</span></td>
<td align="left"><span class="FormData">By Spouse</span></td>
</tr>
</tbody>
</table>
<table width="100%" border="1" cellspacing="0" cellpadding="4">
<thead>
<tr><th width="100%" valign="top" colspan="16" align="center" class="FormTextC">
<b>Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned</b><br><b>(e.g., puts, calls, warrants, options, convertible securities)</b>
</th></tr>
<tr>
<th width="13%" valign="top" rowspan="2" align="left" class="SmallFormText">1. Title of Derivative Security (Instr. 
      3)
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">2. Conversion or Exercise Price of Derivative Security
   </th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3. Transaction Date
      (Month/Day/Year)</th>
<th width="5%" valign="top" rowspan="2" align="left" class="SmallFormText">3A. Deemed Execution Date, if any
      (Month/Day/Year)</th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">4. Transaction Code (Instr. 
      8)
   </th>
<th width="10%" valign="top" colspan="2" align="left" class="SmallFormText">5. 
      Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 
      3, 4 and 5)
   </th>
<th width="9%" valign="top" colspan="2" align="left" class="SmallFormText">6. Date Exercisable and Expiration Date 
      (Month/Day/Year)</th>
<th width="17%" valign="top" colspan="2" align="left" class="SmallFormText">7. Title and Amount of Securities Underlying Derivative Security (Instr. 
      3 and 4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">8. Price of Derivative Security (Instr. 
      5)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">9. 
      Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 
      4)
   </th>
<th width="6%" valign="top" rowspan="2" align="left" class="SmallFormText">10. Ownership Form: Direct (D) or Indirect (I) (Instr. 
      4)
   </th>
<th width="7%" valign="top" rowspan="2" align="left" class="SmallFormText">11. Nature of Indirect Beneficial Ownership (Instr. 
      4)
   </th>
</tr>
<tr>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Code</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">V</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(A)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">(D)</th>
<th width="5%" valign="bottom" align="center" class="SmallFormText">Date Exercisable</th>
<th width="4%" valign="bottom" align="center" class="SmallFormText">Expiration Date</th>
<th width="10%" valign="bottom" align="center" class="SmallFormText">Title</th>
<th width="7%" valign="bottom" align="center" class="SmallFormText">Amount or Number of Shares</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left"><span class="SmallFormData">Restricted Stock Unit</span></td>
<td align="center"><span class="FootnoteData"><sup>(1)</sup></span></td>
<td align="center"><span class="SmallFormData">03/05/2021</span></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">M</span></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">27,566</span></td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">27,566</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0</span><span class="FootnoteData"><sup>(1)</sup></span>
</td>
<td align="center"><span class="SmallFormData">0</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr>
<tr>
<td align="left"><span class="SmallFormData">Restricted Stock Unit</span></td>
<td align="center"><span class="FootnoteData"><sup>(3)</sup></span></td>
<td align="center"><span class="SmallFormData">03/08/2021</span></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">M</span></td>
<td align="center"></td>
<td align="center"></td>
<td align="center"><span class="SmallFormData">21,467</span></td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(3)</sup></span>
</td>
<td align="center">
<span class="SmallFormData">
                
            </span><span class="FootnoteData"><sup>(3)</sup></span>
</td>
<td align="center"><span class="SmallFormData">Common Stock</span></td>
<td align="center"><span class="FormData">21,467</span></td>
<td align="center">
<span class="SmallFormText">$</span><span class="SmallFormData">0</span><span class="FootnoteData"><sup>(3)</sup></span>
</td>
<td align="center"><span class="SmallFormData">21,466</span></td>
<td align="center"><span class="SmallFormData">D</span></td>
<td align="left"></td>
</tr>
</tbody>
</table>
<table border="0" width="100%">
<tr><td class="MedSmallFormText"><b>Explanation of Responses:</b></td></tr>
<tr><td class="FootnoteData">1. Each restricted stock unit represents a contingent right to receive one share of common stock.  The vesting schedule for the 82,700 restricted stock units is as follows: 27,567 shares vested on March 5, 2019; 27,567 shares vested on March 5, 2020; 27,566 shares vested on March 5, 2021.  Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.</td></tr>
<tr><td class="FootnoteData">2. The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in footnote (1) herein.</td></tr>
<tr><td class="FootnoteData">3. Each restricted stock unit represents a contingent right to receive one share of common stock. The vesting schedule for the 64,400 restricted stock units is as follows: 21,467 shares vested on March 8, 2020; 21,467 shares vested on March 8, 2021; 21,466 shares will vest on March 8, 2022.Vested restricted stock units can be settled in shares of common stock, cash or a combination of both.</td></tr>
<tr><td class="FootnoteData">4. The transaction reported represents the withholding of shares by the issuer to satisfy the reporting person's tax withholding obligations in connection with the vesting and settlement of the restricted stock unit award reported in footnote (3) herein.</td></tr>
<tr><td class="FormText"><b>Remarks:</b></td></tr>
<tr><td class="FootnoteData"></td></tr>
</table>
<table width="100%" border="0">
<tr>
<td width="60%"></td>
<td width="20%"><u><span class="FormData">Peter Kies</span></u></td>
<td width="20%"><u><span class="FormData">03/09/2021</span></u></td>
</tr>
<tr>
<td></td>
<td class="MedSmallFormText">** Signature of Reporting Person</td>
<td class="MedSmallFormText">Date</td>
</tr>
<tr><td colspan="3" class="MedSmallFormText">Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.</td></tr>
<tr><td colspan="3" class="MedSmallFormText">* If the form is filed by more than one reporting person, 
                  <i>see</i>

                  Instruction 
                  4

                  (b)(v).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">** Intentional misstatements or omissions of facts constitute Federal Criminal Violations 
                  <i>See</i>

                  18 U.S.C. 1001 and 15 U.S.C. 78ff(a).</td></tr>
<tr><td colspan="3" class="MedSmallFormText">Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, 
                  <i>see</i>

                  Instruction 6 for procedure.</td></tr>
<tr><td colspan="3" class="MedSmallFormText"><b>Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.</b></td></tr>
</table>
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